EDUCATION

ACADEMIC CAREER

RESEARCH AREAS

1)     Protein modification with genetically encoded unnatural amino acids;

2)     Genetically encoded fluorescent or bioluminescent probes;

3)     Protein-based drugs;

4)     Development of new biotechnology

HONORS and AWARDS

2011, the Second-Place Award in the Graduate Poster Competition, the First Annual Research Symposium, Department of Chemistry & Chemical Biology, University of New Mexico.

2005-2006, an honor of Excellent Student Leadership in the city of Tianjin.

2003-2005, an honor for Three A’s student in two consecutive years.

2004. 10, an honor of G. Stork Scholarship.

SELECTED PUBLICATIONS

1. Xuan, W.;^§Yao, A.;^§Schultz PG. Genetically encoded fluorescent probe for detecting sirtuins in living cells. J. Am. Chem. Soc., 2017, 139 (36), pp12350–12353.

2. Xuan, W.; Schultz, PG. A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids. Angew. Chem. Int. Ed. 2017, 56, 9170-9173.

3. Xuan, W.; Shao, S.; Schultz, PG. Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Aryl Carbamate Side Chains. Angew. Chem. Int. Ed. (hot paper) 2017, 56, 5096–5100.

4. Xuan, W.; Li, J.; Luo, X.; Schultz, PG. Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins. Angew. Chem. Int. Ed. 2016, 55, 10065-10068.

5. Xuan, W.;^§Pan, R.^§(equal contribution); Wei Y.; Cao, Y.; Li, H.; Liang, FS.; Liu, K.; Wang, W. Reaction-based “off-on” Fluorescent Probe Enabling Detection of Endogenous Labile Fe²⁺ and Imaging of Zn²⁺ - induced Fe²⁺ Flux in Living Cells and Elevated Fe²⁺ in Ischemic Stroke. Bioconjugate Chem., 2016, 27, 302−308.

6. Xiao, H.;^§Xuan, W.^§(equal contribution); Shao, S.; Liu, T.; Schultz, P. G. Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones. ACS Chem. Biol. 2015, 10, 1599−1603. 

7. Xuan, W.; Cao, Y; Zhou, J.; Wang, W. A FRET-based ratiometric fluorescent and colorimetric probe for facile detection of organophosphonate nerve agent mimic DCP. Chem. Commun., 2013, 49, 10474—10476.

8. Xuan, W.; Pan, R.; Cao, Y.; Liu, K.; Wang, W.A fluorescent probe capable of detecting H₂S at submicromolar concentrations in cells. Chem. Commun., 2012, 48, 10669-10671 

9. Xuan, W.; Chen, C.; Cao. Y.; He, W.; Jiang, W.; Liu, K.; Wang, W. Rational design of a ratiometric fluorescent probe with a large emission shift for the facile detection of Hg²⁺. Chem. Commun., 2012, 48, 7292–7294.

10. Xuan, W.; Sheng, C.; Cao, Y.; He, W.; Wang, W. Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems (highlights). Angew. Chem. Int. Ed. 2012, 51, 2282 – 2284.