苗志伟-元素有机化学研究所

研究队伍s

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苗志伟教授博士生导师

Prof. Zhi-Wei Miao ( Z.-W. Miao )

Tel: 86-22-23504783

E-mail: miaozhiwei@nankai.edu.cn

EDUCATION

1999-2002	Department of Chemistry, Tsinghua University, Beijing, CHINA. Received Ph.D. degree in June, 2002 (with Prof. Yu-Fen Zhao).
1994-1998	Department of Chemistry, Tianjin Normal University, Tianjin, CHINA. Received M. Sc. Degree in March, 1998
1987-1991	Department of Chemistry, Tianjin Normal University, Tianjin, CHINA. Received B. Sc. Degree in June, 1991

ACADEMIC CAREER

2018-Now	Professor, State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.
2012-2018	Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.
2004-2011	Associate Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.
2002-2004	Postdoctoral associate, <span color:black;text-decoration:none;"="">Department of Chemistry and Applied Biosciences, ETH Zȕrich, Zȕrich, Switzerland. (with Professor Andrea Vasella)

1998-1999	Lecturer, Department of Chemistry, Tianjin Normal University, Tianjin, CHINA.

RESEARCH AREAS

(1) Organophosphorus Chemistry.

(2) Asymmetric Catalysis and Synthetic Methodology

(3) Applied organic chemistry and agrochemistry

HONORS AND AWARDS
2018 Distinguished Teacher of Nankai University（南开大学教学名师）
2014-2019 Tianshan Scholar in Xinjiang Uygur Autonomous Region（新疆维吾尔自治区天山学者）

SELECTED PUBLICATIONS

Cheng Cheng, Jiayong Zhang, Xue Wang and Zhiwei Miao* DBU-Promoted [4+4]-Domino Cycloaddition of Ynones with Benzylidenepyrazolones to Access Eight-Membered Cyclic Ethers. J. Org. Chem. 2018, 83, 5450-5457.
Shuang Liu, Yuming Li, Zhiyu Yin, Qiuli Yu and Zhiwei Miao* Diastereoselective Synthesis of Adjacent P,C-Stereogenic β-N-Glycosidic Linkaged α-Aminophosphinates. J. Org. Chem. 2017, 82, 2481-2488.
Jiayong Zhang, Cheng Cheng, Dian Wang and Zhiwei Miao* Regio- and Diastereoselective Construction of Spirocyclopenteneoxindoles through Phosphine-catalyzed [3+2] Annulation of Methyleneindolinone with Alkynoate Derivatives. J. Org. Chem. 2017, 82, 10121-10128.
Yuming Li, Haikun Zhang, Rong Wei and Zhiwei Miao* Chemo- and Diastereoselective Construction of Indenopyrazolinesviaa Cascade aza-Michael/Aldol Annulation of Huisgen Zwitterions with 2-Arylideneindane-1,3-diones. Adv. Synth. Catal. 2017, 359, 4158-4164.
Jiayong Zhang, Minxuan Zhang, Yuming Li, Shang Liu and Zhiwei Miao* Diastereoselective Synthesis of Cyclopentene Spiro-rhodanines Containing Three Contiguous StereocentersviaPhosphine-catalyzed [3+2] Cycloaddition or One-pot Sequential [3+2]/[3+2] Cycloaddition. RSC Adv. 2016, 6, 107984-107993.
Yan Cai, Yuming Li, Minxuan Zhang, Jiaxin Fu, and Zhiwei Miao* Regioselective BF₃·Et₂O-catalyzed C-H Functionalization of Indoles and Pyrrole with Reaction of α-Diazophosphonates. RSC Adv. 2016, 6, 69352-69356.
Weiping Zheng, Jiayong Zhang, Shuang Liu, Chenbin Yu and Zhiwei Miao* Asymmetric Synthesis of Spiro[chroman-3,3’-pyrazol] Scaffolds with an All-carbon Quaternary Stereocenterviaaoxa-Michael-Michael Cascade Strategy with Bifunctional Amine-thiourea Organocatalysts. RSC Adv. 2015, 5, 91108-91113.
Yu Jia, Xiao Tang, Guowei Cai, Ruxuan Jia, Boran Wang, and Zhiwei Miao* Nucleophilic Bisphosphine-catalyzed One-pot Sequential [4+2]/[4+2] Annulation of Allenoate with Benzylidene Pyrazolone. Eur. J. Org. Chem. 2015, 4720-4725.
Chengbin Yu, Weiping Zheng, Junchen Zhan, Yuchao Sun, and Zhiwei Miao* Highly Regio- and Diastereoselective Construction of Spirocyclopenteneoxindole Phosphonates Through Phosphine-catalyzed [3+2] Annulation Reaction. RSC Adv. 2014, 4, 63246–63253.
Yan Cai, Haihong Ge, Chengbin Yu, Weize Sun, Junchen Zhan and Zhiwei Miao* Regiospecific and Highly Stereoselective Synthesis of β-Amino (Z)-Enylphosphonatesviaβ-Hydrogen Migration Reaction of Dialkyl α-Diazophosphonates Catalyzed by AgOTf. RSC Adv. 2014, 4, 21492-21496.
Yan Cai, Hairong Lyu, Chengbin Yu, Zhiwei Miao* Unexpected Stereoselectivity Synthesis of (Z)-β-Alkenyl Substituted β-Amino Phosphonates Through β,γ-Dihydrogen Shift Reaction Catalyzed by [Cu(MeCN)₄]PF₆/I₂. Adv. Synth. Catal. 2014, 356, 596-602.
Chengbin Yu, Hairong Lyu, Yan Cai, Xinyu Miao, Zhiwei Miao* An environmentally benign approach for the synthesis of 3,3’-pyrrolidonyl spirooxindole derivatives via cascade Knoevenagel/Michael/cyclization multicomponent reaction. RSC Adv. 2013, 3, 18857-18862.
Yan Cai, Yuchen Lu, Chengbin Yu, Hairong Lyu, Zhiwei Miao* Combined C-H Functionalization/O-H Insertion Reaction to Form Tertiary β-Alkoxy Substituted β-Aminophosphonates Catalyzed by [Cu(MeCN)₄]PF₆. Org. Biomol. Chem. 2013, 11, 5491-5499.
Gang Hou, Jipan Yu, Chengbin Yu, Guiping Wu, Zhiwei Miao* Enantio- and Diastereoselective Vinylogous Mukaiyama Aldol Reactions of α-Keto phosphonates with 2-(Trimethylsilyloxy)furan Catalyzed by Bis(oxazoline)-copper Complexes. Adv. Synth. Catal. 2013, 355, 589-593.
Weidong Fan, Shasha Kong, Yan Cai, Guiping Wu, Zhiwei Miao* Diastereo- and Enantioselective Nitro-Mannich Reaction of α-Substituted Nitroacetates to N-Phosphoryl Imines Catalyzed by Cinchona Alkaloid Thiourea Organocatalysts.Org. Biomol. Chem. 2013, 11, 3223-3229.
Bing Cui, Gang Hou, Yan Cai, Zhiwei Miao* High diastereoselective vinylogous Mannich reaction induced by O-pivaloylated D-galactosylamine as the chiral auxiliary: stereoselective synthesis of 8-arylazocan-2-one. Carbohydrate RESEARCH 2013, 374, 1-7.
Shasha Kong, Weidong Fan, Guiping Wu, Zhiwei Miao* Enantioselective Synthesis of Tertiary α-Hydroxy Phosphonates Catalyzed by Carbohydrate/Cinchona Alkaloid Thiourea Organocatalysts. Angew. Chem. Int. Ed. 2012, 51, 8864-8867.
Jipan Yu, Xiaona Zhao, Zhiwei Miao* and Ruyu Chen* Highly diastereoselective vinylogous Mukaiyama aldol reaction of α-keto phosphonates with 2-(trimethylsilyloxy)furan catalyzed by Cu(OTf)₂. Org. Biomol. Chem. 2011, 9, 6721-6726.
Yangyun Wang, Jipan Yu,Zhiwei Miao* and Ruyu Chen* Bifunctional primary amine-thiourea–TfOH (BPAT·TfOH) as a chiral phase-transfer catalyst: the asymmetric synthesis of dihydropyrimidines.Org. Biomol. Chem. 2011, 9, 3050-3054.
Jipan Yu,Zhiwei Miao* and Ruyu Chen* Highly efficient asymmetric vinylogous Mannich reaction induced by O-pivaloylated D-galactosylamine as the chiral auxiliary.Org. Biomol. Chem. 2011, 9, 1756-1762.
Haitao Yang, Chao Xi, Zhiwei Miao*, and Ruyu Chen* Cross-Coupling Reactions of Aryl Halides with Amines, Phenols, and Thiols Catalyzed by an N,N’-Dioxide–Copper(I) Catalytic System. Eur. J. Org. Chem. 2011, 18, 3353-3360.
Yangyun Wang, Haitao Yang, Jipan Yu, Zhiwei Miao*, and Ruyu Chen* Highly Enantioselective Biginelli Reaction Promoted by Chiral Bifunctional Primary Amine-Thiourea Catalysts: Asymmetric Synthesis of Dihydropyrimidines. Adv. Synth. Catal. 2009, 351, 3057-3062.
Yadan Wang, Yangyun Wang, Jipan Yu, Zhiwei Miao*, and Ruyu Chen* Stereoselective Synthesis of α-Amino(phenyl)methyl(phenyl)Phosphinic Acids withO-Pivaloylated D-Galactosylamine as Chiral Auxiliary. Chem. Eur. J. 2009, 15, 9290-9293.
Fei Wang, Zhiwei Miao,* and Ruyu Chen* Efficient Syntheses of Phosphonylated Isochromenes by Regioselective 6-Endo-dig Addition to Carbon-Carbon Triple Bond Catalyzed by Pd(OAc)₂. Org. Biomol. Chem. 2009, 7, 2848-2850.
Fei Wang, Yadan Wang, Lingchao Cai, Zhiwei Miao*, and Ruyu Chen Efficient Syntheses of (Thio)phosphonylated Isobenzofurans by Tandem Nucleophilic Addition and Regioselective 5-Exo-digAddition to Carbon-Carbon Triple Bond: Cooperative Effect to DBU.Adv. Synth. Catal. 2008, 350, 2733-2739.
Yadan Wang, Fei Wang, Yangyun Wang, Zhiwei Miao*, and Ruyu Chen. Glycosylation-Induced and Lewis Acid Catalyzed Asymmetric Synthesis ofβ-N-Glycosidically Linkedα-Aminophosphonic Acids Derivatives. Adv. Synth. Catal. 2008, 350, 2339-2344.
Jianfeng Zhang, Zhanwei Cui, Fei Wang, Yadan Wang, Zhiwei Miao* and Ruyu Chen* Mannich type reactions of chlorophosphites, phosphoramides and aldehydes (ketones) under solvent-free and catalyst-free conditions—synthesis of N-phosphoramino α-aminophosphonates. Green Chemistry 2007, 9, 1341-1345.

Zhiwei Miao* “Carbohydrates - Tools for Stereoselective Synthesis” chapter 1-“Reactions of nucleophiles with electrophiles bond to carbohydrate auxiliaries” by the Wiley Publishing Group,2013, ISBN: 978-3-527-32379-1.

REPRESENTATIVE ACHIEVEMENTS

1. Carbohydrates - Tools for Stereoselective Synthesis

2. α-Diazophosphonates - Tools for Synthesis of organophosphorus compounds